Assessment of the eFficacy, the onset-of-Action and the Safety of Tot'héma ® in adults with moderate iron deficiency anaemia

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 121

Inclusion Criteria

Selection criterion
1. Patient with moderate anaemia defined as 8 g/dL = haemoglobin level = 10 g/dL on the last hematological test performed within 7 days before screening visit

Inclusion criteria
1. Adult men and women (=18 years)
2. Patient with a confirmation of moderate anaemia defined as 8 g/dL = haemoglobin level = 10 g/dL on the last hematological test performed within 7 days before inclusion visit
3. Patient with ferritin blood level < lower limit of laboratory standard for this biological parameter on the last hematological test performed within 7 days before inclusion visit
4. Patient who has read, understood, dated and signed the informed consent form
5. Patient agreeing to comply with protocol requirements, including visits and blood samples at specifically defined dates
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 90
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 31

Exclusion Criteria

1. Patient for whom an oral iron supplementation is not indicated or not recommended according to Investigator’s opinion
2. C-Reactive Protein > 10 mg/L on the last hematological test performed within 7 days before inclusion visit
3. Patient with malignant neoplastic tumour
4. Patient presenting gastrointestinal disorders incompatible with study treatment compliance
5. Pregnant or breastfeeding woman
6. Woman with childbearing potential who does not agree to use an accepted highly effective method of contraception – per investigator’s judgment
7. Patient with surgery scheduled to occur during the treatment period
8. Patient allergic or hypersensitive to any of the components of Tot'héma® ampoule
9. Patient with chronic inflammatory disease, including chronic inflammatory bowel syndrome and/or chronic heart failure and/or chronic renal failure and/or inflammatory rheumatism
10. Patient with active digestive bleeding (such as digestive ulcer)
11. Patient having taken iron supplementation, iron-based IV therapy or mineral supplementation with iron within the 15 days prior to the inclusion visit (V2)
12. Patient with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency
13. Patient with acute malaria crisis within 15 days prior to inclusion
14. Patient with a positive Faecal Occult Blood Test (FOBT)
15. Patient with HIV infection
16. Unreliable patients, including non-observant patients, patients with known alcoholism or drug abuse, or with a history of a serious psychiatric disorder, as well as patients who are reluctant to give informed consent or to comply with protocol requirement.
17. Patient with a family relationship to a person at the investigator’s site or at the Sponsor or at the CRO.
18. Participant involved in another interventional or observational clinical trial or who participated in another interventional clinical trial within four weeks before inclusion.

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method

Related Trials