KINO-DYSPNEA: Validation of Kinocardiography to Distinguish Dyspnea of Cardiac Origin From Others

Completed

• Conditions: Dyspnea

• Registration Number: NCT06008600
• Lead Sponsor: Centre Hospitalier Universitaire de Tivoli

Brief Summary

Seismocardiography (SCG) measures the thoracic vibrations caused by the cardiac contraction and ejection of blood into the great vessels. Current smartphones with gyroscopes and accelerometers can measure these vibrations. Based on these components we measure and quantify the cardiac kinetic energy (kinocardiography) in order to differentiate dyspnea of cardiac origin from dyspnea of other origin. The study is conducted in an emergency service where a smartphone performs the measurement during 3 minutes. The results of the kinocardiography-based classification are then compared to the final diagnosis made by a physician. Currently, 235 patients have been included in the clinical study since May 2022. This rapid and non-invasive measurement allows the aid-to-diagnosis of heart failure without being influenced by other factors like the renal function for example that can be NT-pro BNP blood marker.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-19
• Study First Submitted: 2023-05-30
• Study First Submitted QC: 2023-08-18
• Study First Posted: 2023-08-23
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-17
• Last Update Posted: 2025-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 528

Inclusion Criteria

• Dyspnea.
• Adults aged above 18 years old.

Exclusion Criteria

• Patients younger than 18 years old.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the ability of the Kinocardiography technique to discriminate cardiac caused dyspnea from others.	18 months	Area under the receiver operating characteristic curve (AUROC), negative predictive value (NPV) and specificity, with two-sided 95% CIs.

Secondary Outcome Measures

Name	Time	Method
Open retrospective exploratory study to validate the physiological interpretation of Kinocardiography in a clinical environment.	18 months	Establish a link between cardiac kinetic energy distribution in the cardiac cycle between major active clinical syndromes that may be concomitant in the field of cardiac disorders (hypertension, atrial fibrillation, ischemia, valvulopathy, heart-failure,...) and pulmonary (asthma, infection,..). These clinical diagnoses are supported by the physical examination and the patient's medical record at inclusion, with the aid of a measurement of troponin and NTBNP

Trial Locations

Locations (1)

CHU Tivoli; 🇧🇪 La Louvière, Hainaut, Belgium