Duloxetine Role in Reducing Opioid Consumption After Thoracotomy

Phase 4

Completed

• Conditions: Post-thoracotomy Pain
• Interventions: Drug: Oral Duloxetine 60mg; Drug: placebo pill

• Registration Number: NCT03618225
• Lead Sponsor: Assiut University

Brief Summary

A total of 60 patients scheduled for thoracotomy with the aim of excision of pleural or lung cancer, will be randomized by the use of a computer-generated table of random numbers to receive duloxetine 60 mg orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure or a placebo pill following the same time schedule.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-07-14
• Study First Submitted QC: 2018-08-04
• Study First Posted: 2018-08-07
• Study Start: 2018-08-15
• Primary Completion: 2020-01-31
• Study Completion: 2020-01-31
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-13
• Last Update Posted: 2021-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
duloxetine group	Oral Duloxetine 60mg	duloxetine 60 mg orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure.
placebo pill group	placebo pill	placebo pill orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure.

Primary Outcome Measures

Name	Time	Method
Total dose of morphine needed to treat postoperative pain	48 hours	Total dose of morphine needed to treat postoperative pain over 48 hours of study period

Trial Locations

Locations (1)

National Cancer Institute, Cairo University; 🇪🇬 Cairo, Egypt