Duloxetine Role in Reducing Opioid Consumption After Thoracotomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Total dose of morphine needed to treat postoperative pain
研究概览
简要总结
A total of 60 patients scheduled for thoracotomy with the aim of excision of pleural or lung cancer, will be randomized by the use of a computer-generated table of random numbers to receive duloxetine 60 mg orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure or a placebo pill following the same time schedule.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
duloxetine group
duloxetine 60 mg orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure.
干预措施: Oral Duloxetine 60mg (Drug)
placebo pill group
placebo pill orally 2 hours before the surgical procedure and at 24 hours after the surgical procedure.
干预措施: placebo pill (Drug)
结局指标
主要结局
Total dose of morphine needed to treat postoperative pain
时间窗: 48 hours
Total dose of morphine needed to treat postoperative pain over 48 hours of study period
次要结局
未报告次要终点
研究者
Ahmed H Othman
Assisstant professor of Anesthesia ICU and pain Relief
Assiut University