The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV
- Conditions
- PalonosetronAnesthesiaPONV
- Interventions
- Registration Number
- NCT02809378
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may increase patient discomfort, delay patient discharge, and increase the cost of patient care, the risk of postoperative bleeding which may potentially cause airway obstruction.
It is reported that the maintenance of anesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone, but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3 antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly during this period.
The purpose of this study was to evaluate and compare the incidence of PONV after thyroidectomy with three different anesthetic methods, sevoflurane or sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 150
- patients undergoing thyroidectomy euthyroid status American Society of Anesthesiology Physical status 1,2
- Ideal body weight >130% gastrointestinal disease prior administration of anti-emetics (24hr)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sevoflurane pentothal sodium anesthesia induction with pentothal sodium (4-5 mg/kg), maintenance with sevoflurane(1.6-2.5 vol%) sevoflurane, remifentanil, and propofol remifentanil anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%) Sevoflurane, remifentanil, propofol, and palonosetron sevoflurane anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction. sevoflurane, remifentanil, and propofol sevoflurane anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%) Sevoflurane sevoflurane anesthesia induction with pentothal sodium (4-5 mg/kg), maintenance with sevoflurane(1.6-2.5 vol%) sevoflurane, remifentanil, and propofol propofol anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%) Sevoflurane, remifentanil, propofol, and palonosetron Palonosetron anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction. Sevoflurane, remifentanil, propofol, and palonosetron remifentanil anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction. Sevoflurane, remifentanil, propofol, and palonosetron propofol anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction.
- Primary Outcome Measures
Name Time Method incidence of postoperative nausea and vomiting 24 hour postoperative
- Secondary Outcome Measures
Name Time Method incidence of postoperative nausea and vomiting 48 hour postoperative
Trial Locations
- Locations (1)
Ajou universiry hospital
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of