Effects of Helicobacter Pylori Eradication on Symptoms of Parkinson's Disease with Motor Fluctuations

Not Applicable

Completed

• Conditions: Parkinson' s diseaseMotor fluctuations; s disease; Motor fluctuations; Off time; Helicobacter Pylori; 13C- urea breath test

• Registration Number: TCTR20190222005
• Lead Sponsor: Thammasat University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-22
• Study Completion: 2019-10-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Adults (>18 years old) with idiopathic Parkinson's disease
Levodopa therapy required; any formulation is acceptable.
Hoehn & Yahr stage 2-4 in the off state
Motor complications; wearing off
Normal cognition (TMSE >24)
On stable doses of anti-parkinsonian medications or stable DBS adjustment.

Exclusion Criteria

Atypical parkinsonism or secondary parkinsonism
Severe dysphagia
History of gastric cancer, peptic ulcer, duodenal ulcer, or gastric surgery
History of previous brain surgery for PD
Prior treatment for H.pylori
Recent use of proton-pump inhibitor, antibiotics
Allergy to penicillin, amoxicillin, clarithromycin, rabeprazole, metronidazole
Inability to tolerate or participate in testing in the morning in an off state
Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Off time 1 month Average total daily off time from patient symptom diaries in hours

Secondary Outcome Measures

Name	Time	Method
Improvement of UPDRS motor scores 1 month The Unified Parkinson's Disease Rating Scale (UPDRS)