Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: Analysis of molecular alterations by a randomized controlled trial
Not Applicable
- Conditions
- Early gastric cancer or adenoma
- Registration Number
- JPRN-UMIN000006206
- Lead Sponsor
- Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
(1)Patients with malignancy in other organs (2)Patients with having allergy to drugs used for H. pylori eradication (3)Past episode of H. pylori treatment (4)Patients with regularly taking non-steroidal anti-inflammatory drugs (5)Patients with having a past history of esophagectomy or gastrectomy (6)Patients who have determined by the physicians to have any reasons of unqualified
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of biomarkers related to carcinogenesis are evaluated at baseline and 1-yr after intervention with/without H. pylori eradication Primary endpoint: Change of microsatellite instability
- Secondary Outcome Measures
Name Time Method Secondary endpoint: Changes of promoter hypermethylation of some tumor-related genes