A clinical trial for early detection of cervical cancer using optical techniques
- Conditions
- Patients with suspected cervical cancer/ precancerous lesions
- Registration Number
- CTRI/2014/02/004424
- Lead Sponsor
- Centre for Earth Science Studies
- Brief Summary
The study focuses on the noninvasive
detection of cervical pre-cancer/cancer using a spectroscopic point monitoring andimaging systems and to develop an algorithm for grading the entire lesion basedon diffuse reflectance (DR) image ratios and cross validation by pointmonitoring of tissue fluorescence, reflectance and pathology. Spectral variations in the cervix are studied using a fiber-optic pointmonitoring device and based on the recorded spectral variation biopsy will becollected from the measured cervical lesion for pathological correlation. DR image ratio and spectral data are analysed using multivariateanalytical methods and diagnostic accuracies will be calculated by comparingthe optical biopsy diagnosis with tissue biopsy (gold standard). As thesetechniques are comparatively low cost, reliable, non-invasive and real time, itwill have a significant impact on health care in the future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 43
Patients with positive pap smear reports Patients referred for colposcopic examination Patients with any kind of clinically suspecting lesions in the uterine cervix.
Patient refusal Patients with transmittable diseases.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of the malignant site for optimal biopsy and histology; and Reduction of false negatives First arrival at OP clinic
- Secondary Outcome Measures
Name Time Method Reduced trauma, morbidity; and Real-time, Noninvasive diagnosis At the first visit to Clinic
Trial Locations
- Locations (1)
Regional Cancer Centre
🇮🇳Thiruvananthapuram, KERALA, India
Regional Cancer Centre🇮🇳Thiruvananthapuram, KERALA, IndiaDr Suchetha SPrincipal investigator4712522418suchethajyothish@gmail.com