Access Creation for Hemodialysis: Potential Contribution to Left Ventricular Remodelling
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arteriovenous Fistula
- Sponsor
- Ottawa Hospital Research Institute
- Enrollment
- 84
- Locations
- 1
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
Detailed Description
Patients with end stage renal disease are at 18-20 times greater risk of dying from cardiovascular disease as the general population. Both traditional and non-traditional cardiovascular risk factors are thought to be important. Of the non-tradtional cardiovascular risk factors, creation of an arteriovenous fistula or graft for the purposes of a blood access for hemodialysis may contribute to an elevation in BNP and left ventricular hypertrophy - both factors that have been associated with an increased risk of mortality Prior to access creation and at one month and one year post access creation - samples for BNP will be collected Prior to access creation and at one year post access creation - echocardiography will be performed
Investigators
Eligibility Criteria
Inclusion Criteria
- •Hemodialysis 2)high risk for heart failure (DM, age\>50, and/or systolic dysfunction) 3) first arteriovenous fistula/graft 4) informed consent 5) technically adequate echocardiogram 6) stable hgb(\>100) 7) stable mineral metabolism (normal calcium, phosphate \<2.1mmol/L, PTH\>50pmol/L)
Exclusion Criteria
- •Expected survival \<1 year 2) Expected to get a living donor transplant in one year 3)primary access failure 4) ARF
Outcomes
Primary Outcomes
Not specified