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临床试验/CTRI/2025/03/082723
CTRI/2025/03/082723尚未招募不适用

Effectiveness of neurophysiological facilitation on respiratory parameters in mechanically ventilated patients

SRM college of physiotherapy SRM institute of science and technology1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2025年3月25日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
24
试验地点
1
主要终点
Richmonds agitation sedation scale

研究概览

简要总结

BACKGROUND

Mechanical ventilation is a critical life support intervention for patients with respiratory failure  While it provides essential breathing support prolonged use can lead to respiratory muscle weakness This weakness is a significant concern as it can complicate weaning from ventilation and impact overall patient recovery

Neurophysiological Facilitation NPF is an emerging technique that may address this issue NPF involves

Application of tactile stimulation pressure  Utilization of proprioception stretch

These interventions aim to stimulate physiological responses in the respiratory system potentially benefiting patients with respiratory neurological and other systemic diseases affecting respiration

1  NPF has shown promising results in improving various respiratory parameters like Oxygen saturation SpO2 Respiratory rate  Minute volume

2 As a passive manual technique NPF can be applied to a wide range of patients including those who are unconscious paralyzed or on mechanical ventilation

3 The respiratory system involves complex musculature and nerve supplies that can be stimulated to induce physiological changes in respiration

4 Prolonged mechanical ventilation may decrease respiratory reflex mechanisms and muscle tone in both inspiratory and expiratory muscles

5 NPF aims to improve these reflexes and respiratory tone by facilitating neural segments and stretch reflexes

NPF could be a valuable complementary therapy for patients on mechanical ventilation potentially mitigating the negative effects of prolonged ventilator support on respiratory muscle function and facilitating better outcomes in critical care settings

METHODS

A single arm study with two arm parallel group a 6 months randomized experimental study with pre and post intervention assessments involving 24 ICU patients at SRM medical college hospital and research centre designed to evaluate the effectiveness of a specific intervention like Neurophysiological Facilitation in ICU Complex and IMCU of SRM medical college hospital and research centre

DISCUSSION

Conducting the study in a specific ICU setting ensures a controlled environment This research has the potential to contribute valuable insights into the efficacy of NPF in critical care possibly leading to improved respiratory care protocols for mechanically ventilated patients However the limitations of sample size and single center design should be considered when interpreting the results

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
35.00 Year(s) 至 85.00 Year(s)(—)
性别
All

入选标准

  • 1 Both male and female patients will be selected 2 Patients who are under Mechanical Ventilation mode volume control or assist mandatory or intermittent mandatory ventilation 3 Patients who are unconscious due to medical conditions 4 Patients who are moderately sedated 5 patients who are in endotracheal tube and tracheostomy 6 Patients under grade minus one to minus four according to Richmonds Agitation Sedation Scale.

排除标准

  • 1 Conscious oriented alert 2 Patients in noninvasive ventilators 3 Patients who are extremely sedated 4 Patients with chest trauma or rib fracture 5 Patients with any respiratory tract infection 6 Pregnant women and children 7 Malignancies.

结局指标

主要结局

Richmonds agitation sedation scale

时间窗: pre assessment and post assessment

saturation of oxygen

时间窗: pre assessment and post assessment

respiratory rate

时间窗: pre assessment and post assessment

tidal volume

时间窗: pre assessment and post assessment

minute volume

时间窗: pre assessment and post assessment

static compliances and dynamic compliances

时间窗: pre assessment and post assessment

次要结局

  • ICU MOBILITY SCALE(pre assessment and post assessment)

研究者

发起方
SRM college of physiotherapy SRM institute of science and technology
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Prantika Deb

SRM college of physiotherapy SRM institute of science and technology

研究点 (1)

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