Impact of Time Restricted Feeding on Daily Protein Requirements
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Whole-body protein balance
研究概览
简要总结
The investigators aim to assess 24-hour protein kinetics at two different levels of protein intake: 0.8 (RDA) and 1.6g/kg/day (2RDA) during a normal dietary (TRAD) and a time restricted feeding (TRF) pattern in older adults.
详细描述
The investigators aim to assess 24-hour protein kinetics at two different levels of protein intake: 0.8 (RDA) and 1.6g/kg/day (2RDA) during a normal dietary (TRAD) and a time restricted feeding (TRF) pattern in older adults. Individuals in the TRF pattern will only consume food during a 6-hour eating period and fast for the remaining 18 hours. Individuals in the TRAD pattern will consume isocaloric and isonitrogenous (RDA or 2RDA) diet but consume an all-beef-breakfast. Participants will consume oral stable isotopes to measure muscle protein synthesis (MPS), whole-body muscle protein breakdown (MPB), and whole-body protein balance (WBPB). Appropriate muscle, blood samples, and urine will be collected throughout a 24-hour metabolic trial following a 2-day controlled diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women ages 50-75 years.
- •BMI 20-30 kg/m2 inclusive.
- •Capable of providing informed consent.
- •COVID-19 negative and/or asymptomatic
排除标准
- •Subject who does not/will not eat animal protein sources.
- •Body mass index <20 or >
- •Hemoglobin <10g/dL at screening.
- •Platelets <150,000/uL at screening.
- •History of diabetes.
- •History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
- •History of gastrointestinal bypass/reduction surgery.
- •History of a chronic inflammatory disease (e.g. what?)
- •Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
- •Currently using prescription blood thinning medications.
- •Currently using corticosteroid medications.
- •Unable or unwilling to suspend aspirin use for 7 days prior to Visit
- •Unwilling to avoid using protein or amino-acid supplements during participation.
- •Subjects who are unwilling to fast overnight.
- •Participating in >200 minutes/week of vigorous exercise and/or >4 days/week of resistance training.
结局指标
主要结局
Whole-body protein balance
时间窗: 24 hours
Volume of net protein produced per unit of time
次要结局
未报告次要终点