Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI.

Phase 4

Terminated

Conditions: Hypertension
Diabetes Mellitus, Type 2

Interventions: Drug: Carvedilol Controlled Release (CR)
Drug: lisinopril

Registration Number: NCT00430040

Lead Sponsor: University at Buffalo

Brief Summary: To determine whether addition of Carvedilol CR to diabetic patients with hypertension who are receiving the ACEi,Lisinopril,will provide added benefits to blood vessels when compared to treatment with Lisinopril alone.It is believed that carvedilol provides added benefits by suppressing free radicals(charged substances that cause damage to the body ) and inflammation.

Detailed Description: Type 2 diabetes is an atherosclerotic, pro-inflammatory and pro-oxidative stress.Both vascular oxidative stress and inflammation are CVD risk factors and impact endothelial function.

Carvedilol has been demonstrated in preclinical and clinical studies (although limited in size) to exert anti-inflammatory and antioxidant properties: (1) reduce the inflammation markers such as high sensitivity C-reactive protein (hsCRP); (2) reduce oxidative stress via dually eliminating existing reactive oxygen species (ROS) and suppressing the generation of ROS; (3) prevent lipid peroxidation in myocardial cell membrane; (4) protect endothelial and vascular muscle cells from oxygen radical-mediated injury.

This project is about studying the effect of carvedilol CR on blood vessels of diabetic hypertensive patients as compared to Lisinopril alone.

This study involves weaning patient off their current antihypertensive medications and starting them on Lisinopril with Carvedilol CR or lisinopril alone for 6 months and studying the effects of the drugs during this period and thereafter.

Recruitment & Eligibility

Status: TERMINATED

Sex: All

Target Recruitment: 14

Inclusion Criteria

Is male or female >= 18 and <= 70 years of age
Has a documented history of type 2 diabetes mellitus for a minimum of four months prior to the screening visit
Has a documented history of or current presentation with Stage 1 or Stage 2 hypertension and meets one of the following criteria:
Has controlled hypertension (sSBP <130 mmHg AND sDBP <80 mmHg) on >=2 antihypertensive medications NOTE: A combination drug containing two antihypertensive agents represents two antihypertensive medications OR
Has uncontrolled hypertension (sSBP >=130 and <=170 mmHg AND/OR sDBP >=80 and <=105 mmHg) on one or two antihypertensive medications OR
Has newly diagnosed or previously untreated hypertension (sSBP >=130 and <=170 mmHg AND/OR sDBP >=80 and <=105 mmHg
At Randomization, sitting systolic blood pressure (sSBP) >= 130 mmHg or sitting diastolic blood pressure (sDBP) >= 80 mmHg and sSBP <= 170 mmHg and sDBP <= 105 mmHg
Has been on a stable dose of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) for a minimum of four months prior to the screening visit

Exclusion Criteria

Has any clinically significant abnormality identified in the screening physical examination, laboratory tests or electrocardiogram which, in the judgement of the investigator, would preclude safe completion of the study
Is female of childbearing potential
Has any of these cardiac conditions: uncontrollable or symptomatic arrhythmias, unstable angina, sick sinus syndrome or second or third degree heart block (unless treated with a permanent, functioning pacemaker), bradycardia (heart rate <55 bpm), and stroke within three months of study screening, and history of myocardial infarction.
Has Congestive Heart Failure NYHA (New York Heart Association) class II-IV
Has type 1 diabetes mellitus
Has newly diagnosed type 2 diabetes (within 4 months of screening visit)
Has HbA1c > 8.5%
Has the following, as it relates to subject's antidiabetic therapy:Initiated or changed dosage or formulation of thiazolidinediones (TZDs) within 6 months of screening visit.
A history of acute or chronic acidosis, including diabetic ketoacidosis
Has current clinical diagnosis of chronic obstructive pulmonary disease (COPD, e.g., chronic bronchitis) or asthma
Has a history of bronchospastic disease not undergoing active therapy in whom, in the investigator's opinion, treatment with study medication could provoke bronchospasm
Has evidence of any of the following clinically significant diseases that could impair the absorption, metabolism, or excretion of orally-administered medication:
renal disease defined as estimated Glomerular Filtration Rate (eGFR) <60mL/min per 1.73 m2 using the Modification of Diet in Renal Disease (MDRD) formula below: GFR (mL/min/1.73m2) = 186 x [Serum Creatinine (umol/L) x 0.0113]-1.154 x Age(years)-0.203 (x 0.742 if female)
hepatic disease (i.e., ALT or AST levels greater than three times the upper limit of normal range, history of hepatic impairment, or by clinical assessment)
Chronic biliary disorders
Has endocrine disorders (e.g., pheochromocytoma, active and untreated hypo or hyperthyroidism)
Has any known contraindication to ACE inhibitors, alpha- or beta-blocker treatment
Has systemic disease, including cancer, with reduced (<12 months) life expectancy
Has used an investigational drug within 30 days or 5 half-lives (whichever is longer) preceding the first dose of study medication
Has a history of a psychological illness or any condition that would interfere with the subject's ability to understand or complete the requirements of the study

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
carvedilol	Carvedilol Controlled Release (CR)	carvedilol
lisinopril	lisinopril	lisinopril
carvedilol	lisinopril	carvedilol

Primary Outcome Measures

Name	Time	Method
Change in Brachial Artery Vascular Reactivity	6 months	Percent change from baseline in Brachial artery vascular reactivity at 6 months calculated as: (brachial reactivity at 6 months-brachial reactivity at 0 months)/brachial reactivity at 0 month \*100

Secondary Outcome Measures

Name	Time	Method
Change in Oxidative Stress in Mononuclear Cells (MNC)	6 months	Percent change from baseline in Reactive Oxygen species (ROS) generation in MNC at 6 months calculated as: (ROS at 6 months-ROS at 0 months)/ROS at 0 month \*100