iver toxicity of azathioprine and 6-mercaptopurine in IBD patients.
Phase 4
Recruiting
- Conditions
- Nodular regenerative hyperplasianon cirrhotic portal hypertension10017969
- Registration Number
- NL-OMON31453
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
IBD patients
18 years or older
who have been treated at least 5 years with azathioprine and/or 6-mercaptopurine
who give permission for ultrasound guided liverbiopsy and MRI
Exclusion Criteria
anaemia (Hb < 6.5 mmol/L), thrombocytopenia (Thr < 50 * 10 9/L), prolonged INR (INR > 1.5), ascites.
exclusioncriteria for MRI: pacemaker, ICD, metal intracerebral clips, known allergy for contrast agents that are used, claustrophobia.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method