Effect of maternalBMI and Type of Infants Feeding on IGF-1in Infants as Early Marker of Childand Adult Hood Obesity
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Assiut University
- Enrollment
- 40
- Primary Endpoint
- IGF-1 level in infants
Study Overview
Brief Summary
IGF-I is a mitogenic and antiapoptotic. paracrine growth factor expressed in all fetal organ. and is essential in fetal and neonatal growth, differentiation and development Several lines of evidence suggest that IGF-I levels are associated with birth weight -furthermore higher IGF-I levels are associated with higher BW, but not with lower birth weight]. In adulthood, elevated concentrations of IGF-I are associated with an increased risk of obesity and many cancers, including breast, lung, head and neck, colorectal, pancreas, synovial sarcoma, and prostate canc. Although concentrations of circulating IGF-I levels vary considerably by race/ethnicity and maternal pre-pregnancy obesity, few studies included African American women an ethnic group that has an almost 9% higher BMI than European-American women
Detailed Description
For healthy mother ,breastfeeding represent the gold standard for infant health, and infant formula development aims at mimicking the physiological response to human milk intake. while protein content is essential to promote growth and brain development, protein intakes in late infancy have been found to be quite high and to exceed required intakes by large margins )Ohlund and ,Hernell , 2010)
More over ,high protein intake was associated with increased weight gain and higher adiposity in infancy and child hood )Singhal and kennedy , 2010 ) further more, protein intake of breast-fed infant is generally lowerand may relate to lower risk of obesity later in life)Harder and Betgmann , 2005 )
one potential mechanism involves an enhanced stimulation of the secretion of Insulin growth factor(IGF-1)strophic hormone involved in longitudinal growth as well as muscle and fat mass development (Rolland et el,1995 )
• General research statement and Justification of the research
A-Maternal BMI and IGF-1 level in infants There's a positive association among term infant with elevated IGF-1 level and increased risk with higher birthweight. This positive association most apparent in infant born to obese women PubMed).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Screening
- Masking
- None
Masking Description
Measurment of blood level of IGF-1 and Maternal BMI
Eligibility Criteria
- Ages
- 2 Months to 3 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •infants from two to three month and thier mother
Exclusion Criteria
- •1 -VLBW. 2-preterm infants. 3-IUGR 4-mother with hormonal disturbance
Arms & Interventions
level of IGF-1 in infant
Measurment of blood level of IGF-1 In infants
Intervention: level of IGF-1 in infants (Diagnostic Test)
Outcomes
Primary Outcomes
IGF-1 level in infants
Time Frame: One year
Effect of maternal BMI and type of feeding of infants on IGF-1on infants
Secondary Outcomes
No secondary outcomes reported
Investigators
N M Shahata
Nesma Mohamed Ezz ElDien Shahata
Assiut University