Hormonal and metabolic effects of diet and exercise programs in obese women with polycystic ovary syndrome (Hormonella och metabola effekter av diet- och motionsprogram hos överviktiga kvinnor med polycystiskt ovariesyndrom)
Completed
- Conditions
- Polycystic ovary syndrome (PCOS)Nutritional, Metabolic, EndocrinePolycystic ovarian syndrome
- Registration Number
- ISRCTN48342048
- Lead Sponsor
- Karolinska Institute (Sweden)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 45
Inclusion Criteria
Women aged 18-40 years diagnosed with PCOS and having body mass index (BMI) > 27
Exclusion Criteria
1. The presence of other disease or a different endocrine disorder
2. An eating disorder
3. Smoking
4. Continuous medication including insulin sensitising drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immediately before this study, after four months of intervention and at the time of the long-term follow-up, each patient underwent a general health control involving determination of blood pressure, weight, height and waist/hip ratio (WHR).<br><br>1. All gynecological examinations including transvaginal ultrasound using Sonoline SI-250 equipment (Siemens Healthcare Diagnostics, Deerfield, IL, USA) were performed by the same investigator. The ovarian parameters evaluated were the maximal number of follicles in one plane and the volumes of the largest follicle and of the entire ovary. Menstrual bleedings were recorded and ovulation confirmed on the basis of an elevation in the serum level of progesterone during the luteal phase of the menstrual cycle. <br>2. For determination of body composition, the patients were examined by dual energy X-ray absorptiometry (DXA) employing a Lunar Prodigy Advance whole body scanner (GE medical systems, Fairfield, CT, USA).
- Secondary Outcome Measures
Name Time Method Improved insulin sensitivity - In a resting and fasting state at 8:00 am a blood sample was collected from a peripheral vein and the serum separated by centrifugation and stored at ? 70 degree celsius, pending analysis for hormones, binding proteins and glucose. <br><br>Evaluated immediately before this study, after four months of intervention and at the time of the long-term follow-up