Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies
- Registration Number
- NCT02410980
- Lead Sponsor
- University of California, Irvine
- Brief Summary
The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.
- Detailed Description
The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.
1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 15
Inclusion Criteria
- Female 45 years of age or older - Skin type scale I to III
Exclusion Criteria
- Large amount of dark, coarse hair on the arms
- History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
- Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
- History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
- History of diabetes
- Currently pregnant or nursing
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Tretinoin cream 0.1% Tretinoin cream 0.1% Assessment of the skin change
- Primary Outcome Measures
Name Time Method Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas. up to 2 months The effects of tretinoin cream on human skin will be measured.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beckman Laser Institute Medical Clinic
🇺🇸Irvine, California, United States