NCT02410980已完成早期 1 期
In-vivo Non-invasive Skin Imaging Pilot Study to Assess the Effects of Tretinoin Cream Using Multi-photon Microscopy and Multi-spectral Imaging
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas.
研究概览
简要总结
The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.
详细描述
The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.
- Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
- Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female 45 years of age or older - Skin type scale I to III
排除标准
- •Large amount of dark, coarse hair on the arms
- •History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
- •Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
- •History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
- •History of diabetes
- •Currently pregnant or nursing
研究组 & 干预措施
Tretinoin cream 0.1%
Experimental
Assessment of the skin change
干预措施: Tretinoin cream 0.1% (Drug)
结局指标
主要结局
Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas.
时间窗: up to 2 months
The effects of tretinoin cream on human skin will be measured.
次要结局
未报告次要终点
研究者
Beckman Laser Institute and Medical Center
Mihaela Balu, Ph.D. Associate Specialist
University of California, Irvine
研究点 (1)
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