Comparing the Hemodynamic changes and intubating conditions between vecuronium and rocuronium in patients posted for laparoscopic cholecystectomy under general anaesthesia

Not yet recruiting

Conditions: Calculus of gallbladder without cholecystitis,

Registration Number: CTRI/2022/01/039588

Lead Sponsor: Teerthanker Mahaveer Medical College and Research Centre Moradabad UP

Brief Summary: Laparoscopic Cholecystectomy is a gold standardprocedure for management of gall bladder stones and is usually performed undergeneral anaesthesia. The procedure offers several advantages over opentechnique like reduction of stress response of surgery, decrease inpost-operative pain, decrease chances of wound infection and faster recoverywith good cosmetic appearance. Major disadvantages are due to physiological effectsof insufflation of CO2 in the abdomen. Neuromuscular blocking agents are useful in performing endotracheal intubation andproviding surgical relaxation. The onset time, duration of muscle relaxationand type of surgery are major factors that determine the choice of musclerelaxant to be used for the endotracheal intubation and surgical relaxation. Vecuroniumwas the first non-depolarizing neuromuscular blocking agent with anintermediate duration of action to be introduced into clinical practice. With botha shorter duration of action and minimum hemodynamic side effects, it seta standard against which all subsequent neuromuscular blocking agents werecompared. Rocuronium,a non depolarising muscle relaxant, was first introduced and marketed in the UnitedStates. It is known for its rapid onset and intermediate duration of action. Added advantage of Rocuronium is the rapidonset and it is excreted unchanged in urine, hence eliminating the side effectscaused by the metabolites.

**AIM****:** Comparison of hemodynamic changes in patientsundergoing Laparoscopic Cholecystectomyusing Rocuronium and Vecuronium for intubation and maintenance under generalanaesthesia.

**OBJECTIVES****:**

1.Tomeasure intubating condition

2.Tomeasure hemodynamic changes during intubation

3.Tomeasure hemodynamic changes during maintenance of general anaesthesia.

4.Torecord complications, if any.

The study will be conducted after obtaining clearance from the Institutional Ethical Committee and written informed consent from the patients. patients will be explained about the drugs being used in the in their own language and will also be explained that they can belong to either of the two groups. patients will be randomly divided in two groups by "chit and box" method. Control group will be given injection vecuronium 0.1mg/kg and study group will be given injection rocuronium 0.6mg/kg.

Intubatingconditions will be graded and assessed according to scoring of endotrachealintubating conditions by Cooper et al. Hemodynamic parameters : Heart rate,Blood Pressure, MAP and SPO2 will be recorded timely. Statisticalanalysis will be done using appropriate test.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

American Society of Anesthesiologists (ASA) grade I and II scheduled for surgery under general anesthesia.
Patients with BMI of 18.5-22.9 kg/m2.

Exclusion Criteria

Patients undergoing surgery with moderate to severe blood loss.
Patients who are allergic to pre-treatment or study drugs.
Systemic disorders like cardiovascular , pulmonarv, hepatorenal, metabolic diseases.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To note the ease of intubation and any hemodynamic changes with respect to heart rate, blood pressure, MAP.	After muscle relaxant, before intubation, 1 and 5 minute after intubation, before skin incision, 1 minute after skin incision,before carboperitoneum, 1 minute after carboperitoneum, 1 , 5, 10, 15, and 20 minutes after giving the drug, before extubation and 1minute and 5 minute after extubation

Secondary Outcome Measures

Name	Time	Method
To look for any complications such as arrhythmias, ischemic changes or hypotension	at every 5 mins after induction and every 5 mins post extubation for upto 30 mins

Trial Locations

Locations (1): Teerthanker Mahaveer Medical College and Research Centre, Moradabad, UP
🇮🇳
Moradabad, UTTAR PRADESH, India
Teerthanker Mahaveer Medical College and Research Centre, Moradabad, UP
🇮🇳Moradabad, UTTAR PRADESH, India
Dr Nikhita Juneja
Principal investigator
9582574454
junejanikhita@gmail.com