Comparison Between Mean Duration of Post-operative Analgesia of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine Following Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Duration of analgesia
研究概览
简要总结
For patients with symptomatic cholelithiasis, laparoscopic cholecystectomy (LC) is a customary procedure for treatment these days. After LC, patients may experience considerable pain. This study was performed with the objective of comparing the mean duration of analgesia of intraperitoneal bupivacaine with dexmedetomidine to intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of either gender
- •Aged between 20 and 70 years
- •ASA (American Society of Anesthesiologists Classification) physical status I and II
- •Undergoing Laparoscopic Cholecystectomy under general anesthesia
排除标准
- •Patients sensitive to local anesthetics
- •Patients with acute cholecystitis, choledocholithiasis, or ascending cholangitis (temperature≥38.6°C, serum bilirubin≥1.2mg/dl, and ultrasound showing common bile duct diameter of ≥1cm).
- •Patients with uncontrolled diabetes (FBS≥110 mg/dl)
- •Uncontrolled blood pressure (SBP≥140 mmHg)
- •Ischemic heart disease (EF≤40%)
- •Pulmonary dysfunction (FEV≤70 percent of normal)
研究组 & 干预措施
Bupivacaine group
Patients received intraperitoneal bupivacaine 50 ml 0.25% + 5 ml normal saline
干预措施: Bupivacaine injection (Drug)
Bupivacaine + Dexmedetomidine group
Patients were given intraperitoneal bupivacaine 50 ml 0.25% + dexmedetomidine 1 μg/kg with normal saline 5 ml
干预措施: Bupivacaine injection (Drug)
Bupivacaine + Dexmedetomidine group
Patients were given intraperitoneal bupivacaine 50 ml 0.25% + dexmedetomidine 1 μg/kg with normal saline 5 ml
干预措施: Dexmedetomidine injection (Drug)
结局指标
主要结局
Duration of analgesia
时间窗: 24 hours
The duration of postoperative analgesia was calculated as the time in minutes starting after the dressing of the patient in the operation room until the patient had a VAS≥3.
次要结局
未报告次要终点
研究者
Muhammad Aamir Latif
Research Consultant
RESnTEC, Institute of Research