Dietary antioxidant intervention for reversal of airway inflammation and respiratory illness in athletes.

Completed

• Conditions: Airway inflammation; Respiratory illness; Respiratory - Other respiratory disorders / diseases; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12613001290785
• Lead Sponsor: niversity of Newcastle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-11-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Subjects must have trained regularly (at least 5 times per week ~>40 km running.wk-1) for at least 1 year, and a treadmill V02 >45 ml.kg-1.min-1.

Exclusion Criteria

Any diagnosed health condition affecting respiratory and immune function e.g. asthma

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Eosinophilic airway inflammation will be determined by fractional exhaled nitric oxide.[Baseline, 2, 4 and 6 weeks]

Secondary Outcome Measures

Name	Time	Method
Respiratory symptoms will be assessed using a symptom and illness log developed validated by the Australian Institute of sport. This questionnaire has been previously approved by the University of Newcastle ethics committee (H-2012-0121) and is also available online.[Baseline, 2, 4 and 6 weeks];Systemic Inflammation and oxidative stress will be determined from laboratory analysis of collected blood samples. Biomarkers of inflammation will include IL-6, IL-10 and CRP and of oxidative stress will include thiobarbituric acid reactive substances (TBARS).[Weeks 0, 2, 4 & 6]