Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- Ruijin Hospital
- Enrollment
- 1000
- Locations
- 8
- Primary Endpoint
- The change of incidence of cognitive impairment
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological and digital markers to explore new solutions such as dementia disease mechanism, diagnosis, condition evaluation, and prognosis assessment.
Detailed Description
This project will build a longitudinal database based on multimodal MRI imaging information of dementia subjects, various body fluid or digital markers, and a cohort. The convolutional neural network algorithm will be used to explore the imaging characteristics of healthy controls, AD, FTD, and DLB, develop an early prediction model for degenerative dementia, and achieve early differential diagnosis of different dementia subtypes. This study further performed GE180, ASEM, and exendin-4 radionuclide imaging on some subjects who completed conventional PET (AV45, Tauvir, and FDG) imaging to explore the diagnostic efficacy of these three probes as new diagnostic probes for early AD. In addition, through longitudinal follow-up of Aβ-positive MCI patients, multimodal MRI and PET image fusion technology were used to explore the changes in fused images during their conversion to AD in order to obtain early and accurate diagnostic markers.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged ≥50 and ≤85 years old, male or female;
- •Meet the diagnostic criteria for dementia or MCI;
- •Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form
Exclusion Criteria
- •The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
- •The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
- •Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
- •The presence of contraindications to MRI;
- •The presence of mental and neurological retardation;
- •Refusing to draw blood;
- •Refusing to sign the informed consent form.
Outcomes
Primary Outcomes
The change of incidence of cognitive impairment
Time Frame: baseline, 1 year, 2 year, 3 year, 4 year
Number of participants who covert to AD or mild cognitive impairment (MCI) will be recorded to calculate the incidence.
Secondary Outcomes
- The change of speech information(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of structural MRI(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of Geriatric Depression Scale (GDS)(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of electroencephalogram (EEG)(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of Mini-Mental State Examination (MMSE)(baseline, 1 year, 2 year, 3 year, 4 year)
- Positron emission tomography (PET)-MRI(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of Activities of daily living (ADL)(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of Montreal cognitive assessment-Basic (MoCA)(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of Auditory verbal learning test (AVLT)(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of functional MRI(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of magnetic susceptibility(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of perfusion MR imaging(baseline, 1 year, 2 year, 3 year, 4 year)
- The change of blood biomarker(baseline, 1 year, 2 year, 3 year, 4 year)