Treatment for gum diseases using nanoparticles

Not yet recruiting

Conditions: Chronic periodontitis,

Registration Number: CTRI/2021/03/032008

Lead Sponsor: JSS Academy of Higher Education and Research Institute

Brief Summary: **Pre-surgical procedures:**

Patients fulfilling the inclusion criteria and have willingly given informed consent will be subjected to phase-1 therapy comprising of full-mouth scaling, root planing, and occlusal corrections if required.

The subjects will be monitored for plaque control and tissue response and if found satisfactory will be prepared for surgery. Gingival index and plaque index will be recorded at baseline on the day of surgery. Intraoral radiographs with the grid will be taken by using paralleling technique to record osseous defect depth, Alveolar crest level.

**Method:**

Following local anesthesia with 2% Lignocaine, using block and infiltration techniques, intra-crevicular incisions will be given to reflect the full thickness mucoperiosteal flaps for defect access and debridement.

The patients will be randomly divided into two study groups by computer alloted method

**GROUP-A** {Test group}; Intra-bony defects will be filled with injectable nano hydroxyapatite-chitosan scaffold.

**GROUP-B** {Control group}; Intrabony defects will be filled with nano-hydroxyapatite bone graft.

The surgical flaps will be repositioned and sutured using 4-0 black silk to achieve primary closure.

post-operative instructions will be given.

**Post-surgical Evaluation:**

Patients will be recalled after 7 days for surgical removal

Recall examinations will be scheduled at 3,6,9 months postoperatively and all the clinical parameters will be recorded

Radiographic parameters(IOPAR with grid) and CBCT will be assessed at baseline and after 9 months

Patients will be monitored periodically for their oral hygiene maintenance.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Subjects with more than 20 remaining teeth Subjects with Chronic Periodontitis with Periodontal pocket depth greater than 5mm Systemically healthy subjects with any vertical bone loss.

Exclusion Criteria

Pregnant and lactating mothers, smokers Allergic to chitosan/HAP Compromised immune system Undergone periodontal therapy in previous 6 months Subjects taking medication that could interfere with soft tissue/bone healing.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periodontal regeneration	Baseline,3,months, 6 months,9months

Secondary Outcome Measures

Name	Time	Method
To reduce Periodontal pocket depth	Baseline,3,months, 6 months,9months

Trial Locations

Locations (1): JSS Dental College and Hospital
🇮🇳
Mysore, KARNATAKA, India
JSS Dental College and Hospital
🇮🇳Mysore, KARNATAKA, India
Kalyanam Rashmi Durga
Principal investigator
9573638899
rashmikalyanam10@gmail.com