Evaluation of the Signaling Path of Emiline1-TGFβ in the Myogenic Tone of Resistance Arteries in a Population of Normotensive and Hypertensive Subjects

Completed

• Conditions: Hypertension

• Registration Number: NCT02312193
• Lead Sponsor: Neuromed IRCCS

Brief Summary

Aim of this study is to enhance the knowledge of myogenic tone alterations in hypertensive patients and to better understand the mechanisms controlling the myogenic tone. Evaluations will be performed through ex vivo studies of peripheral arterioles in human adipose tissue from lumbar muscle, isolated from biopsies. This will allow investigators to evaluate the myogenic function in response to progressive blood pressure increases, in order to correlate myogenic function to arterial hypertension and to the molecular mechanisms already identified in the preclinical models.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-11-28
• Study First Submitted QC: 2014-12-05
• Study First Posted: 2014-12-09
• Study Start: 2015-01
• Primary Completion: 2020-12
• Study Completion: 2020-12
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-03
• Last Update Posted: 2022-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 95

Inclusion Criteria

• Males or females between 30 and 70 years of age
• Hypertensive patients: Patients with a previous diagnosis of hypertension
• Normotensive patients: subjects without story of hypertension
• Written informed consent

Exclusion Criteria

• Severe hypertension (eg, systolic >180 mm Hg, diastolic >110 mm Hg)
• Manifested or suspected secondary hypertension (coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, pheochromocytoma)
• History of cardiac complications (previous acute myocardial infarction (AMI), unstabile angina, percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass grafting (CABG), congestive heart failure (NYHA II-IV))
• Diabetes mellitus
• Renal pathologies (creatinine clearance < 30 ml/min)
• Severe hepatic dysfunction

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Myogenic tone measured by micromyographic technique to evaluate small-artery morphology.	12 months

Trial Locations

Locations (1)

IRCCS Neuromed; 🇮🇹 Pozzilli, Isernia, Italy