The Analysis of Blood Stasis Syndromeand of Coronary Heart Disease Related MicroRNA Genomics and Target Gene Regulatory Networks
试验速览
- 阶段
- 2 期
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- the change of Cycle threshold of relational microRNA in coronary artery disease with unstable angina
研究概览
简要总结
In this study, typical cases of blood stasis syndrome of coronary heart disease are selected, by using microRNA chip, cDNA microarray and other bioinformatics technologies to filter and verify related miRNA and its target gene of Coronary Heart disease. Meanwhile, intervene by Xuesaitong soft capsules to investigate related miRNA and its target gene of Coronary Heart disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of coronary angiography unstable angina
- •Clinical diagnosis of unstable angina
- •Age of 30 to 75 years old
- •Not use thrombolysis, dilate coronary drugs within two weeks
- •Tongue dark
- •Sign the consent
排除标准
- •Severe valvular heart disease
- •Insulin-dependent diabetes
- •mental disease
- •Combined with severe liver, kidney, hematopoietic system disorder
- •Patients with malignant tumors
- •Pregnancy or breast-feeding women
- •Recent history of trauma
- •Drug allergy
研究组 & 干预措施
Xuesaitong soft capsule group
Patients who confirmed by coronary angiography and diagnosed blood stasis syndrome of coronary heart disease are given conventional Western medicine treatment and Xuesaitong soft capsule.
干预措施: Xuesaitong soft capsule (Drug)
control group
Patients who confirmed by coronary angiography and diagnosed blood stasis syndrome of coronary heart disease are given conventional Western medicine treatment and placebo.
干预措施: Xuesaitong soft capsule Placebo (Drug)
结局指标
主要结局
the change of Cycle threshold of relational microRNA in coronary artery disease with unstable angina
时间窗: 1 month
The change of Cycle threshold of relational microRNA in coronary artery disease with unstable angina by real RT-PCR.
次要结局
未报告次要终点