Effects of Exercise Training on Endothelial Function, Heart Rate Variability, Exercise Capacity, and Quality of Life in Patients With Permanent Atrial Fibrillation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Change of exercise capacity (after intervention)
研究概览
简要总结
Atrial fibrillation (AF) is a common arrhythmia. The proposed patholophysiological mechanisms of AF include abnormal electrical conduction in atrium and sympathovagal imbalance with increased vagal tone. Patients with AF have poor exercise capacity that may contribute to decreased atrial effective refractory period, and decreased cardiac output and heart rate reserve, and may result in poor quality of life. Poor endothelial function had been noted in patients with AF, associated with increased risks of cerebrovascular and cardiovascular disease. Exercise training has been noted to improve exercise capacity and quality of life in patients with AF only in some studies. Endothelial function can be improved by exercise training in patients with cardiovascular disease, but no report in patients with AF. Evidence of exercise training is still needed in patients with AF. The purpose of this study is to investigate the effect of exercise training on
- endothelial function
- heart rate variability
- exercise capacity
- quality of life.
详细描述
A randomized controlled study was implemented to examine :(1) the effect of interval aerobic exercise training combined with resistance training on endothelial function, heart rate variability (HRV), exercise capacity, and quality of life (QoL); (2) the influential factors related to exercise capacity, and the relationship between exercise capacity and quality of life in patients with permanent atrial fibrillation (AF).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 76 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Permanent atrial fibrillation≥ 1 year aged 40-76 years
- •Recurrence AF after ablation
- •Under antiarrhythmia medication control
排除标准
- •CAD or myocardial infrarction history
- •NYHA≥ III-IV, or LVEF≤45%
- •Mitral or aortic valve regurgitation ≥ Gr. II
- •Mitral valve or aortic valve stenosis
- •Pacemaker
- •Cardioversion by ablation
- •Pulmonary artery hypertension
- •Any surgery in previous 3 months
- •Any neurological disorders
- •Severe musculoskeletal disorder
- •Hyperthyroidism
- •Premenopausal women
研究组 & 干预措施
Exercise training
Exercise group will undergo progressively aerobic exercise training with 40-85% maximal oxygen consumption for 40 minutes, 3 sessions per week for 12 weeks.
干预措施: Exercise training (Other)
control group
Control group conducted the usual care
结局指标
主要结局
Change of exercise capacity (after intervention)
时间窗: At baseline and 12 weeks after intervention
To measure maximal oxygen consumption, maximal oxygen pulse, maximal heart rate and blood pressure, cumulated and peak workload by cycle ergometer with Vmax 229 system
次要结局
- Change of heart rate variability (after intervention)(At baseline and 12 weeks after intervention)
- Change values of head up tilt test (after intervention)(At baseline and 12 weeks after intervention)
- Change of endothelial function (after intervention)(At baseline and 12 weeks after intervention)
- Change of quality of life (after intervention)(At baseline and 12 weeks after intervention)