Mommy-Baby Treatment for Perinatal Depression

Not Applicable

Completed

• Conditions: Depressive Disorder, Major; Postpartum Depression
• Interventions: Other: Enhanced Treatment as Usual; Behavioral: Dyadic Interpersonal Psychotherapy

• Registration Number: NCT01744041
• Lead Sponsor: Washington University School of Medicine

Brief Summary

Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. Despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. The purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, Interpersonal psychotherapy for the mother-infant dyad (IPT-Dyad). This intervention begins during pregnancy and continues with the mother and infant until one year postpartum. The investigators hypothesize that IPT-Dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2012-11-27
• Study First Submitted QC: 2012-12-04
• Study First Posted: 2012-12-06
• Primary Completion: 2017-01-31
• Study Completion: 2017-01-31
• Results First Submitted: 2021-10-06
• Status Verified: 2021-12
• Results First Submitted QC: 2021-12-16
• Last Update Submitted: 2021-12-16
• Results First Posted: 2022-01-11
• Last Update Posted: 2022-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 42

Inclusion Criteria

• Pregnant women
• 18 years and older
• between 12 and 30 weeks gestation
• Score greater than or equal to 13 on Edinburgh Depression Scale
• Structured Clinical Interview (SCID-IV) diagnosis of Major Depressive Disorder, dysthymia, or Depressive Disorder, Not otherwise Specified
• English Speaking

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Exclusion Criteria

• Substance abuse or dependence in past 3 months
• Active suicidal or homicidal ideation
• Bipolar disorder, psychotic disorder
• unstable medical condition or other medical/obstetrical complication
• Evidence of severe intimate partner violence
• Ongoing psychosocial or pharmacotherapy for depression

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Enhanced Treatment as Usual	Enhanced Treatment as Usual	Personalized referral to community resources for depression treatment
Dyadic Interpersonal Psychotherapy	Dyadic Interpersonal Psychotherapy	Brief Interpersonal Psychotherapy during pregnancy followed by dyadic mother-infant psychotherapy for one year postpartum

Primary Outcome Measures

Name	Time	Method
Change in Edinburgh Depression Scale From Baseline	Change from baseline at End of pregnancy (between 37-39 weeks gestation); change from baseline at 3 months postpartum; change from baseline at 6 months postpartum; change from baseline at 9 months postpartum; change from baseline at 12 months postpartum	Edinburgh Postnatal Depression Scale, a 10-item scale of depression severity, scores range from 0 to 30 with higher scores indicating worse outcome.

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States