Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia Under Intraoperative fMRI
Overview
- Phase
- Phase 4
- Intervention
- Dexmedetomidine Injectable Solution
- Conditions
- Not specified
- Sponsor
- China International Neuroscience Institution
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Measurement of analgesia relative brain regions assessed by BOLD under fMRI scanning
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Background: Dexmedetomidine (Dex) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting analgesia of Dexmedetomidine. Methods: Select 28 patients with the proposed intraoperative MR-guided radiofrequency ablation of epilepsy. The subjects were randomized into the Dexmedetomidine group (Dex group) (n=14) and the Placebo group (PO group) (n=14). DEX group: continuous intravenously administered 1.5 µg kg-1 h-1 dexmedetomidine 15min before anesthesia induction, continuous infusion for 15min after anesthesia induction, and then Intraoperative functional magnetic resonance imaging scanning was started. PO group: the equivalent administered speed 0.9% sodium chloride was continuously pumped for 15min before anesthesia induction, then induce and intraoperative fMRI scanning started after continuous 30min infusion. The intraoperative fMIR scan results were compared and analyzed to find the unique analgesic brain regions of DEX, and the differences of the functional neuronal network of analgesia effect between the two groups.
Detailed Description
Background: Dexmedetomidine (DEX) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting analgesia of Dexmedetomidine. Methods: Select 12 patients with the proposed intraoperative MR-guided radiofrequency ablation of epilepsy. The subjects were randomized into the Dexmedetomidine group (DEX group) (n=14) and the Placebo group (PO group) (n=14). DEX group: continuous intravenously administered 1.5 µg kg-1 h-1 dexmedetomidine 15min before anesthesia induction, continuous infusion for 15min after anesthesia induction, and then Intraoperative functional magnetic resonance imaging scanning was started. OPI group: the equivalent administered speed 0.9% sodium chloride was continuously pumped for 15min before anesthesia induction, then induce and intraoperative fMRI scanning started after continuous 30min infusion. The intraoperative fMIR scan results were compared and analyzed to find the unique analgesic brain regions of DEX, and the differences of the functional neuronal network of analgesia effect between the two groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of epilepsy and eligible for radiofrequency ablation
- •20-50 years old;
- •American Society of Anesthesiologists rated (ASA) I-II
- •body mass index (BMI)18.5\~27.9 kg·m2.
Exclusion Criteria
- •pre-existing neuropsychiatric disorders;
- •emergency surgery;
- •depression;
- •cognitive impairment;
- •implanted with metal devices.
Arms & Interventions
Dexmedetomidine group
1.5 µg kg-1 h-1 dexmedetomidine
Intervention: Dexmedetomidine Injectable Solution
Placebo group
0.9% sodium chloride injection
Intervention: Sodium Chloride 0.9% Inj
Outcomes
Primary Outcomes
Measurement of analgesia relative brain regions assessed by BOLD under fMRI scanning
Time Frame: during operation
Measurement of analgesia relative brain regions inDexmedetomidine group (DEX group) and the Opioid group (OPI group) assessed by BOLD under fMRI scanning, and compare the two group different at the same time
Secondary Outcomes
- diastolic blood pressure (DBP)(during operation)
- mean arterial pressure (MAP)(during operation)
- NRS(Hour 4, Hour 12, Hour48 post-operatively)
- Measurement of analgesia relative brain regions assessed by T1-MPRAGE under fMRI scanning(during operation)
- heart rate (HR)(during operation)
- Measurement of analgesia relative brain regions assessed by T2-SPACE under fMRI scanning(during operation)
- systolic blood pressure (SBP)(during operation)