FSH receptor polymorphisms and treatment of poor responders

• Conditions: poor response in assisted reproduction techniques (IVF/ICSI); 10014701; 10013356

• Registration Number: NL-OMON31719
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 112

Inclusion Criteria

Inclusion criteria are 2 ovaries in situ, less than 1,5 years between the two treatments, the use of a GnRH-agonist in the short protocol using 450 units of FSH, a minimum of one previous IVF or ICSI cycle in which the dosage FSH was less than 450 units of FSH (i.e. 225 or 300 IU/day), a long suppression protocol and a GnRH-agonist was used.

Exclusion Criteria

Exclusion criteria are removal of one ovary, more than 1,5 years between the treatments, the use of a GnRH-antagonist and no previous IVF/ ICSI cycle(s) or previous cycles in which the dosage was also 450 units of FSH or a short protocol was used.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-The FSH receptor polymorphism genotype.<br /><br>-The number of growing follicles and retrieved oocytes per treatment cycle. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>