Genetic variants of sex hormone receptors in patients with atrial fibrillatio

Recruiting

• Conditions: I48; Atrial fibrillation and flutter

• Registration Number: DRKS00033526
• Lead Sponsor: Klinikum Bielefeld Mitte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients with atrial fibrillation (ICD-10 code: I48.0 or I48.1) > 18 years of age
- Postmenopausal status in women (last menstrual period > 12 months ago). Premenopausal women would experience excessive hormonal fluctuations due to their menstrual cycle.
- Ability to give consent and sufficient knowledge of German

Exclusion Criteria

- Obesity = size II (BMI = 35kg/m2)
- Manifest hyperthyroidism (TSH < 0.25 µIU/ml)
- Harmful alcohol use according to ICD10/WHO definition
- The following valve conditions: mitral valve stenosis, moderate/high-grade aortic valve stenosis, moderate/high-grade mitral valve insufficiency
- Postoperative status (operation < 10 d)
- Sepsis according to WHO definition
- Acute or chronic infections (CRP > 15 mg/dl)
- Indications of CHD (corresponding symptoms, echocardiographic or ECG morphological abnormalities) or already diagnosed CHD
- Hypokalemia (K+ < 3.0 mmol/l)
- Acute or chronic right heart strain (systolic pulmonary artery pressure (sPAP) = 36 mmHg in transthoracic echocardiography) (e.g. pulmonary artery embolism or COPD)
- Obstructive sleep apnea syndrome (OSAS)
- Chronic renal insufficiency
- (uncontrolled) arterial hypertension
- (Z.n.) malignant gynecological tumor disease, (Z.n.) prostate carcinoma, (Z.n.) hormonally active tumors
- Z.n. ovariectomy or Z.n. orchiectomy
- Hormone metabolism disorders with an influence on sex hormone levels
- Daily intake of NSAIDs (diclofenac, ASA, naproxen or ibuprofen),
- Intake of opiates or cortisone compounds
- Hormonal therapy
- Non-consenting ability

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Prevalence of genetic variants in sex hormone receptor genes and associated proteins in patients with atrial fibrillation and gender differences of these variants<br>- Prevalence of altered cellular signal transduction by sex hormone receptor variants in patients with atrial fibrillation

Secondary Outcome Measures

Name	Time	Method
Sex hormone levels in patients with atrial fibrillation compared to patients without atrial fibrillation