Sex hormones, sex chromosomes, and sexual differentiation of the brai

Completed

• Conditions: Sexual differentiation of the brain; disorder of sex development; testicular feminization; 10038608; 10040480

• Registration Number: NL-OMON36349
• Lead Sponsor: etherlands Institute for Neuroscience

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

All subjects: Right-handed, Normative olfactory performance,Written informed consent obtained;Healthy Volunteers: Heterosexual orientation, Sex-typical gender identity;Transsexual controls: Genetically male, sex-atypical gender identity;Patients: Diagnosis of complete androgen insensitivity syndrome (CAIS)

Exclusion Criteria

All subjects: Smoking, Excessive drug/alcohol use, Psychiatric and Neurological illness, Significant physical illness (excluding diagnosis of CAIS), Anosmia or hyposmia, MRI contraindications ;Healthy Volunteers (20 men and 20 of 40 women): Hormone therapy or birth control pills

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The parameters of interest include brain morphology, the ability to detect AND,<br /><br>CEOAE scores, 2D:4D ratios, brain activity in the resting state as well as in<br /><br>response to AND presentation and two cognitive tasks during the fMRI<br /><br>experiment, and estrogen (estradiol and ethinylestradiol), LH, FSH,<br /><br>progesterone and testosterone levels on the test day.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>