The biochemical and molecular identity of hormones in the human heart
Not Applicable
Recruiting
- Conditions
- cardiologyHeart transpantCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12618001163291
- Lead Sponsor
- The Christchurch Heart Institute Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
All participants on the cardiac transplant waiting list aged 18-63
will be invited to participate.
Exclusion Criteria
unable or unwilling to participate
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite clinical outcomes include success of transplantation, rejection events, morbidity with respect to alternate organ failure and general outcomes such as exercise ability etc. This data is obtained via the NZ Heart Transplant Program Medical Records system.[ The time points of <30 days, 6 months, and then yearly assessments.]
- Secondary Outcome Measures
Name Time Method A secondary outcome will be more precise and sophisticated mass spectrometry analysis of target peptides in explant heart tissue.[ at the time of transplant];The cause of heart failure or disease requiring transplant will be correlated with the peptide modifications observed. We will simply observe if the presence or absence of peptide modifications bear any relationship the etiology of the explanted hearts. The presence or absence of peptide modifications will be assessed by high performance liquid chromatography and mass spectrometry<br><br>[ At the time of transplant<br>]