Changes in gastrointestinal hormones after bariatric surgery

Completed

• Conditions: Morbid obesity; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN12131308
• Lead Sponsor: San Carlos Clinical Hospital (Hospital Clínico San Carlos)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02-01
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Obese participant inclusion criteria:
1. Aged between 18 and 65 years
2. BMI = 40 kg/m2 or = 35 kg/m2 with associated major comorbidities likely to improve after weight loss
3. That morbid obesity is set for at least 5 years.
4. Continuing failures to properly supervised conservative treatments
5. Ability to understand the mechanisms by which weight is lost with surgery and understand that good results are not always achieved
6. Understand that the goal of surgery is not reach the ideal weight
7. Commitment to adhere to the rules of follow-up after surgery
8. Informed consent after receiving all the (oral and written) information

Control participant inclusion criteria:
1. Aged between 18 and 65 years
2. No diabetes mellitus (basal glucose <126 mg/dl and/or Hba1c < 6.5%)
3. BMI <30 and >18 kg/m2
4. No drugs or alcohol abuse.
5. No mayor psychiatric disorders (schizophrenia, psychosis) no eating disorders( anorexia nervosa, bulimia)
6. Informed consent after receiving all the (oral and written) information

Exclusion Criteria

1. Endocrine disorders that can cause morbid obesity.
2. Psychological instability including abuse of alcohol or drugs, major psychiatric disorders (schizophrenia, psychosis), mental retardation, eating disorders (bulimia nervosa, binge eating)
3. Pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hormonal response after meal test is measured from blood samples taken at baseline, 30, 60, 90 and 120 minutes after ingestion of a standard test meal, at baseline and one year post surgery.

Secondary Outcome Measures

Name	Time	Method
Weight loss and the height was measured using an electric scale (SECA®) at baseline, 1, 3 and 5 years.