Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response
Completed
- Conditions
- Fertility Disorders
- Interventions
- Other: blood sample
- Registration Number
- NCT03007043
- Lead Sponsor
- Institut Universitari Dexeus
- Brief Summary
To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 364
Inclusion Criteria
- Age between 18-38 years old
- BMI 18-28
- Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml
- 1st or 2nd ovarian stimulation cycle for IVF/ICSI
- Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol
Exclusion Criteria
- Antral follicle count (AFC) <9 and AMH<1.1 ng/ml
- PCOS patients according to the Rotterdam criteria
- Patients undergoing in vitro maturation (IVM)
- Untreated endocrine abnormalities
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Normal responders blood sample Normal response following IVF Suboptimal responders blood sample Suboptimal response following IVF
- Primary Outcome Measures
Name Time Method prevalence of the main FSH receptor polymorphism 12 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy HCMC, Ho Chi Minh City, Vietnam and Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University HCMC
🇻🇳Ho Chi Minh City, Vietnam
Dexeus Salud de la Mujer
🇪🇸Barcelona, Spain