Abnormal sex hormone exposure of the brain; possible neuroendocrine implications for cognition in adult transsexuals and women with polycystic ovarian syndrome as clinical models

Completed

• Conditions: Geslachtsaanpassende behandeling voor genderdysforie; Polycyctic ovarian syndrome; transsexuality; 10018515

• Registration Number: NL-OMON36332
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- Gender identity disorder according DSM-IV-TR
- Polycystic ovary syndrome (PCOS) with clinical or biochemical signs of
hyperandrogenism
- Eligible for hormone treatment

Exclusion Criteria

- Persons with insufficient command of the Dutch language
- Unadjusted endocrine disorders
- Current treatment with sex steroids
- Neurological or psychiatric disorders that could lead to deviant test results
- Neuropharmacological intervention
- Alcohol (>5 units per day) or drug abuse
- Contra indications for an MRI scan
- Excessive androgen production other than the hypersecretion of androgens from
the ovaries
- Pregnancy (excluded by a pregnancy test)
- Current desire to have children

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• Blood oxygen level dependent (BOLD) response in functional MRI<br /><br>• Test results from the neuropsychological assessments</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Reproductive endocrine serum samples<br /><br>• Blood pressure<br /><br>• Anthropometric measurements<br /><br>• Depression score<br /><br>• Anxiety score</p><br>