Research of possible effect of sex steriods to the brain.
Recruiting
- Conditions
- Hormones, cognition, functional MRI, transsexualism, polycystic ovarian syndrome, PCOS, estrogens, androgens
- Registration Number
- NL-OMON22065
- Lead Sponsor
- - Stichting wetenschappelijk onderzoek (SWOG)Contactgegevens:VU University Medical CenterDepartment of obstetrics and gynaecologyp.o. box 7057, 1007 MB AmsterdamThe NetherlandsTelephone: +31-20-4444444- Neuroscience campus Amsterdam (NCA)VU University Medical CenterDepartment of Medical Psychologyp.o. box 7057, 1007 MB AmsterdamThe NetherlandsTelephone: +31-20-4444444
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Gender identity disorder according DSM-IV-TR;
2. Polycystic ovary syndrome (PCOS) with clinical or biochemical signs of hyperandrogenism;
Exclusion Criteria
1. Persons with insufficient command of the Dutch language;
2. Unadjusted endocrine disorders;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Blood oxygen level dependent (BOLD) response in functional MRI;<br /><br>2. Test results from the neuropsychological assessments. We will evaluate different cognitive domains with a neuropsychological test battery. The cognitive domains to be evaluated are attention, perceptual speed, memory (verbal and visual) and executive functioning (working memory, fluency and set shifting). We will also<br>present a task to estimate the intelligence level and questionnaires to gather information about the medical history, socio-demographic characteristics and anxiety or depression (SCL '90, HADS).
- Secondary Outcome Measures
Name Time Method 1. Reproductive endocrine serum samples;<br /><br>2. Blood pressure;<br /><br>3. Anthropometric measurements;<br /><br>4. Depression score;<br /><br>5. Anxiety score.