Investiagtion of hormonal aspects of synaptic plasticity using a human surrogate model for central sensitizatio
Not Applicable
- Conditions
- Pain
- Registration Number
- DRKS00012301
- Lead Sponsor
- Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerztherapie Universitätsklinikum Münster
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 37
Inclusion Criteria
voluntariness, age 18 - 40 years, regular menstrual cycle varying from 26 to 30 days
Exclusion Criteria
pregnancy, lactation, any medication (e. g. hormonal contraceptives, homones, anabolic steroids, analgesic, antidepressants), any pre-existing medical conditions (e.g. diabetes, migraine, multiple sclerosis, psychiatric disorder) or withdrawal of consent
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Baseline measurement: mechanical pain threshold (with PinPrick; MPT), mechanical pain sensibility (MPS), electrical pain sensibility (EPS), electrical detection threshold (EDT)<br>T0: immediatley after high frequency stimulation (HFS): MPT, MPS, EPS, EDT<br>T1: 1 hour after HFS: MPT, MPS, EPS, EDT<br>T3: three hours after HFS: MPT, MPS, EPS, EDT plus blood sampling<br>T27: 27 hours after HFS: MPT, MPS, EPS, EDT<br><br><br>Three measurements: follicular phase, late follicukar phase, luteal phase<br><br>High levles of progesterone (luteal phase) might amplify an induced primary and/ or secondary hyperalgesia. High levels of estrogen (late follicular phase) might decrease induced hyperalgesia.
- Secondary Outcome Measures
Name Time Method Measurement for area of hyperalgesia using a brush<br>T0;<br>T1;<br>T3; <br>T27.<br><br>Regression analysis might detect different gonodal hormones constellations that cause hyperalgesia.