Investigation of response of glioblastomas to cytotoxic drugs in vitro (ivt Study)

• Conditions: glioblastoma; C71.9; Brain, unspecified

• Registration Number: DRKS00000264
• Lead Sponsor: niversitätsklinikumRheinisch-Westfälische Technische Hochschule Aachen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11-13
• Study Completion: 2012-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

new radiological diagnosis of a malignant glioma (MRT based)
indication for surgical resection
Karnofsky index of at least 70%
no principal denial of chemotherapy
no serious hematological, liver, kidney abnormalities precluding chemotherapy
written informed consent of the patient

Exclusion Criteria

younger than 18 or older than 75 years
preoperative a/o intraoperative verification of a pathology, incompatible with a malignant glioma (WHO grade III/IV)
no histologically confirmed glioblastoma
tumor infiltrates areas of the brain that preclude an adequate radiation dose
prior tumor surgery or other treatment
Karnofsky index of less than 70%
severe cardiovascular disease
severe hematological impairment, kidney a/o liver insufficiency which preclude chemotherapy
stroke
serious infection
basic unwillingness to receive chemotherapy
other malignancies (except basalioma)
pregnancy or lactation
women in childbearing age if contraception cannot be warranted
dementia or other mental state which precludes comprehension of therapy and hence, informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
time to progression (TTP)

Secondary Outcome Measures

Name	Time	Method
overall survival (OS)