Imaging and Treatment Planning for Cardiac Radioablation

Not Applicable

Not yet recruiting

• Conditions: Ventricular Tachycardia, Monomorphic; Ventricular Tachycardia (V-Tach); Ventricular Tachycardia (VT)

• Registration Number: NCT06938074
• Lead Sponsor: Stewart Gaede

Brief Summary

The purpose of this study is to (1) determine whether computed tomography (CT) imaging can be used to identify areas of ischemic scar, which are often used as radiation targets for cardiac radioablation, just as well as MRI can, and (2) to determine how best to deliver cardiac radioablation treatment to a patient, for example, which treatment machine should be used and how to limit the effect of chest movement during treatment.

Participants will undergo two separate imaging appointments: one CT imaging appointment, where they will undergo scans including perfusion scans, late enhancement scans, and radiation therapy treatment planning scans; and one MRI appointment, where they will undergo scans including a late enhancement scan. The overlap in areas of ischemic scar as identified in CT scans and MRI scans will be quantified.

Using radiation therapy treatment planning CT scans, the safety and feasibility of different treatment and motion management techniques will be evaluated. Treatment plans will be created using these different techniques and will be compared to one another. These plans will also be evaluated for compliance with dose constraints.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study First Submitted: 2025-04-07
• Study First Submitted QC: 2025-04-14
• Last Update Submitted: 2025-04-14
• Study First Posted: 2025-04-22
• Last Update Posted: 2025-04-22
• Study Start: 2025-07-01
• Primary Completion: 2026-07-01
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Similarity and overlap of areas of ischemic scar defined in CT and MRI as evaluated by similarity metrics (Dice Similarity Coefficient, Hausdorff Distance)	6 months after conclusion of study	Areas of ischemic scar, as defined using CT, will be compared to those defined using MRI.
Safety and deliverability of cardiac radioablation treatments, as evaluated by adherence to institutional dose-volume histogram constraints (safety) and accurate delivery to a phantom (deliverability)	6 months after conclusion of study	Treatment plans created using different linear accelerators and motion management techniques will be compared to determine whether dose constraints are met. Plan deliverability will be determined. This will be completed using patient CT scans, patients will not undergo any radiation therapy.

Trial Locations

Locations (1)

London Health Sciences Centre Research Inc; 🇨🇦 London, Ontario, Canada