Arm Swing During Walking in Early Multiple Sclerosis

Completed

• Conditions: Upper Extremity Problem; Multiple Sclerosis; Gait Disorders, Neurologic
• Interventions: Other: Evaluation of the arm swing during gait; Other: Functional Tests

• Registration Number: NCT05821257
• Lead Sponsor: Istanbul University - Cerrahpasa (IUC)

Brief Summary

Multiple sclerosis (MS) is the most common central nervous system inflammatory demyelinating disease which causes motor and sensory deficits, cerebellar symptoms, and balance problems. Due to these symptoms, gait abnormalities are common in MS, even in patients with low degrees of impairment. The upper limb has an important role on postural control and gait stability. Affected arm swing movement and asymmetry during gait are common in neurological disorders such as Parkinson's disease (PD) even in early stages of the disease and arm swing treatment has been acknowledged to enhance gait and normalize arm swing in individuals with PD.

The presence of arm swing changes during walking in MS patients, similar to PD, especially in the early period, may be an indicator of balance problems, this was, however, not investigated as such. Therefore, the aim of the current study is to assess the arm swing during gait in people with MS shortly after their diagnosis in early MS.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-01
• Study First Submitted: 2023-03-27
• Study First Submitted QC: 2023-04-06
• Study First Posted: 2023-04-20
• Primary Completion: 2023-05-31
• Study Completion: 2023-06-30
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-26
• Last Update Posted: 2023-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Patients who were diagnosed with MS in the last 30 days,
• Patients who were recovered from their symptoms and were clinically stable

Exclusion Criteria

• Patients who had an acute medical illness in the past 6 months, any other neurological and psychiatric diseases
• Patients who had any orthopedic, rheumatologic, or vestibular conditions that affect walking
• Patients who had exacerbations between the first and second evaluations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Early Multiple Sclerosis	Functional Tests	Arm swing evaluation and functional tests will be tested in this group.
Healthy Controls	Evaluation of the arm swing during gait	Arm swing evaluation will be tested in this group.
Early Multiple Sclerosis	Evaluation of the arm swing during gait	Arm swing evaluation and functional tests will be tested in this group.

Primary Outcome Measures

Name	Time	Method
Arm swing amplitude-shoulder degrees in flexion-extension direction	3 months after the baseline	The difference between the maximum flexion and extension of the shoulder will be calculated with Kinovea video player.
Arm swing amplitude-elbow degrees in flexion-extension direction	3 months after the baseline	The difference between the maximum flexion and extension of the shoulder will be calculated with Kinovea video player.
Arm swing amplitude-overall degrees in flexion-extension direction	3 months after the baseline	The difference between the maximum flexion and extension of the shoulder will be calculated with Kinovea video player.
Step-speed	3 months after the baseline	The stepping task required patients to walk back and forth for 2 minutes over a three meters walkway which was set up with the FreeMed foot pressure analysis system (Sensor Medica, Guidonia Montecelio). Step speed outcome was collected from foot pressure analysis system.
Two Minute Walk Test (2MWT)	3 months after the baseline	It is a measure of self-paced walking ability and functional capacity. The person is encouraged to walk as fast as they can, safely, without assistance for two minutes and the distance is measured.
Timed Up and Go (TUG)	3 months after the baseline	To determine fall risk and measure the progress of balance, sit to stand and walking.It uses the time that a person takes to rise from a chair, walk three meters, turn around 180 degrees, walk back to the chair, and sit down while turning 180 degrees.
Timed 25Foot Walk Test (T25FW)	3 months after the baseline	The T25-FW is a quantitative mobility and leg function performance test based on a timed 25-walk.

Trial Locations

Locations (1)

Istanbul University-Cerrahpaşa; 🇹🇷 Istanbul, Turkey