Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Efficacy Perineural DxaM
研究概览
简要总结
The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pre-surgical total knee arthroplasty patients
排除标准
- •Skin infection near block site
- •Allergy to local anesthetics
- •Peripheral neuropathy
- •Proven opioid dependency
- •Coagulopathy
研究组 & 干预措施
Group I (ISB-P)
Four nerve blocks with perineural injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml
干预措施: Dexamethasone (Drug)
Group I (ISB-P)
Four nerve blocks with perineural injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml
干预措施: Bupivacaine (Drug)
Group II (ISB-S)
Four nerve blocks with systemic injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml
干预措施: Dexamethasone (Drug)
Group II (ISB-S)
Four nerve blocks with systemic injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml
干预措施: Bupivacaine (Drug)
Group III (ISB-C)
Four nerve blocks without dexamethasone
干预措施: Bupivacaine (Drug)
结局指标
主要结局
Efficacy Perineural DxaM
时间窗: One day
Duration of motor and sensory block
次要结局
- Efficacy of Systemic DxaM(One day)