Y-PRP Trial : Yoga enhanced PRP vs Conventional PRP- Growth factor assessment and functional outcomes in early knee osteoarthritis

Patients presenting with symptoms of knee pain, crepitus, and/or stiffness will be assessed and recruited in the Orthopaedics OPD in PGIMER. A detailed history, general health check-up and a clinical examination of the knee will be performed for each subject to make a differential diagnosis. This examination will include a general physical examination, knee examination, and x-ray of both knees to confirm the diagnosis of OA. The x-rays will be taken in two orthogonal views: a standing anteroposterior and a 30-60° accurate lateral view, through a digital radiographic machine and print on a standard x-ray film will be taken for analysis and grading of OA. Patients with symptomatic KL grade 1 or 2 knee OA fulfilling the inclusion criteria will be recruited for the study after taking written informed consent. All patients will be assessed for pain, stiffness, and functional status using a validated score for knee OA i.e. Western Ontario and McMaster Universities Arthritis Index Questionnaire (WOMAC) score29. Pain in the affected knee joint will be assessed using the Visual Analog Scale(VAS)30. Psychological Scoring will also be done using DASS 2131 Scale to rule out any distress or anxiety-related factors which may affect patient satisfaction after the injection.