Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Osteoporosis
- 发起方
- University of Missouri-Columbia
- 入组人数
- 12
- 主要终点
- serum bone turnover markers
- 状态
- 已完成
- 最后更新
- 9年前
概览
简要总结
We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.
详细描述
Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.
研究者
入排标准
入选标准
- •No symptoms of disease
- •Non-sedentary
- •Age 25-65
排除标准
- •Medications or supplements that affect bone metabolism or prevent exercise
- •Previous or current medical condition affecting bone health, including osteoporosis.
- •Cardiovascular disease
- •Metallic implants affecting accuracy of bone density scan
- •Current smoker
- •Current participation in high-intensity jumping or resistance exercise in the last 3 months.
结局指标
主要结局
serum bone turnover markers
时间窗: 24 hours
次要结局
- serum hormones regulating bone turnover(24 hours)