Effects of Glucose-fructose Drinks During Training on Lactate Transport

Not Applicable

Completed

• Conditions: Normal Physiology on Healthy Subjects
• Interventions: Dietary Supplement: Glucose-fructose; Dietary Supplement: Water

• Registration Number: NCT01610986
• Lead Sponsor: University of Lausanne

Brief Summary

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Detailed Description

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2012-05-23
• Study First Submitted QC: 2012-05-30
• Study First Posted: 2012-06-04
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Status Verified: 2014-06
• Last Update Submitted: 2014-06-03
• Last Update Posted: 2014-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 17

Inclusion Criteria

• healthy
• age between 18 and 30 years
• sedentary
• BMI between 19 and 25
• blood pressure lower than 140/90 mmHg

Exclusion Criteria

• smoking
• consumption of more than 10g alcohol per day
• cardiovascular history
• electrographic abnormalities at rest
• consumption of more than one can of soda per day or more than 60g sugars per day
• any current drug treatment
• consumption of drugs or illicit substances
• diabetes mellitus
• vegetarian
• food intolerance
• blood donation or participation to another study <3 months before study inclusion

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Glucose-fructose	Glucose-fructose	Participants will take glucose-fructose drinks during training sessions
Water	Water	Participants will take only water during training sessions

Primary Outcome Measures

Name	Time	Method
Change in lactate transport	At baseline (before training) and after the 3-week training protocol	Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)

Secondary Outcome Measures

Name	Time	Method
Change in muscle monocarboxylate transporters (MCTs) expression and protein content	At baseline (before training) and after the 3-week training protocol	MCTs expression (mRNA) and protein content after muscle biopsy

Trial Locations

Locations (1)

University of Lausanne; 🇨🇭 Lausanne, Vaud, Switzerland