Effect of 0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia Among Hospitalized Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 103
- 试验地点
- 1
- 主要终点
- oral bacterial colonization status
研究概览
简要总结
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.
详细描述
Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized patients > 20 years old without ventilator
排除标准
- •known hypersensitivity to or intolerance of Chlorhexidine or Listerine
研究组 & 干预措施
0.12% chlorhexidine
Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers.
干预措施: 0.12% Chlorhexidine Oral Liquid Product (Drug)
Listerine
Participants will be randomized to Listerine solution group, applied twice a day by care givers.
干预措施: Listerine Oral Liquid Product (Drug)
Normal saline
Participants will be randomized to Normal saline group, applied twice a day by care givers.
干预措施: Normal Saline Product (Other)
结局指标
主要结局
oral bacterial colonization status
时间窗: 1 year
次要结局
- The rate of non-ventilator associated pneumonia(1 year)
研究者
Chen, Yen-Chin
Vice Head Nurse and Clinical Assistant Professor
National Cheng-Kung University Hospital