0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia
Not Applicable
Completed
- Conditions
- Hospital-acquired Pneumonia
- Interventions
- Other: Normal Saline ProductDrug: Listerine Oral Liquid Product
- Registration Number
- NCT04403971
- Lead Sponsor
- National Cheng-Kung University Hospital
- Brief Summary
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.
- Detailed Description
Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 103
Inclusion Criteria
- Hospitalized patients > 20 years old without ventilator
Exclusion Criteria
- known hypersensitivity to or intolerance of Chlorhexidine or Listerine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Normal saline Normal Saline Product Participants will be randomized to Normal saline group, applied twice a day by care givers. Listerine Listerine Oral Liquid Product Participants will be randomized to Listerine solution group, applied twice a day by care givers. 0.12% chlorhexidine 0.12% Chlorhexidine Oral Liquid Product Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers.
- Primary Outcome Measures
Name Time Method oral bacterial colonization status 1 year
- Secondary Outcome Measures
Name Time Method The rate of non-ventilator associated pneumonia 1 year
Trial Locations
- Locations (1)
Yen-Chin Chen
🇨🇳Tainan, Taiwan