Effect of 0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia Among Hospitalized Patients
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 103
- Locations
- 1
- Primary Endpoint
- oral bacterial colonization status
Overview
Brief Summary
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.
Detailed Description
Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Sequential
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Hospitalized patients \> 20 years old without ventilator
Exclusion Criteria
- •known hypersensitivity to or intolerance of Chlorhexidine or Listerine
Arms & Interventions
0.12% chlorhexidine
Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers.
Intervention: 0.12% Chlorhexidine Oral Liquid Product (Drug)
Listerine
Participants will be randomized to Listerine solution group, applied twice a day by care givers.
Intervention: Listerine Oral Liquid Product (Drug)
Normal saline
Participants will be randomized to Normal saline group, applied twice a day by care givers.
Intervention: Normal Saline Product (Other)
Outcomes
Primary Outcomes
oral bacterial colonization status
Time Frame: 1 year
Secondary Outcomes
- The rate of non-ventilator associated pneumonia(1 year)
Investigators
Chen, Yen-Chin
Vice Head Nurse and Clinical Assistant Professor
National Cheng-Kung University Hospital