Prevalence and Risk Factors of COVID-19 in the Upper Silesian Agglomeration
- Conditions
- Severe Acute Respiratory SyndromeCovid19Virus DiseaseCorona Virus InfectionRespiratory Tract InfectionsRNA Virus InfectionsRespiratory Tract Disease
- Interventions
- Diagnostic Test: IgM and IgG antibodies assay
- Registration Number
- NCT04627623
- Lead Sponsor
- Medical University of Silesia
- Brief Summary
Project is designed as a comprehensive population-based epidemiological study in Upper-Silesian Conurbation (Poland) aiming at:
1. analysis of available data on incidence and mortality due to COVID-19 and
2. estimation of the occurrence of viral infection SARS-CoV-2 as revealed by the results of serological test (ELISA: IgM, IgG), with assessment of risk factors.
The project's objectives are: to assess incidence and mortality due COVID-19 according to sex, age and coexisting diseases; to determine the level of potential "underdiagnosis" of the magnitude of COVID-19 mortality using vital statistics data for Upper-Silesian Conurbation; to assess the prevalence of SARS-CoV-2 based on the level of seropositivity in Upper-Silesian Conurbation; to identify host-related and environmental risk factors if the infection. Analysis of existing data will include monthly records on incidence and mortality over the period 01.01.2020-31.12.2020 and comparison of the findings with the monthly records of 2018 and 2019, for the same population. Cross-sectional epidemiological study will be located in three towne (Katowice, Sosnowiec, Gliwice). In each town a representative age-stratified sample of 2000 subjects will undergo questionnaire assessment and serological examination performed by serological test. The project corresponds with analogous population-based studies on COVID-19 in a number of countries and responds to the WHO recommendation in that field.
- Detailed Description
Project is designed as a comprehensive population-based epidemiological study in Upper-Silesian Conurbation (Poland) aiming at:
1. analysis of available data on incidence and mortality due to COVID-19 and
2. estimation of the occurrence of viral infection SARS-CoV-2 as revealed by the results of serological test (ELISA: IgM, IgG), with assessment of risk factors.
The project's objectives are: to assess incidence and mortality due COVID-19 according to sex, age and coexisting diseases; to determine the level of potential "underdiagnosis" of the magnitude of COVID-19 mortality using vital statistics data for Upper-Silesian Conurbation; to assess the prevalence of SARS-CoV-2 based on the level of seropositivity in Upper-Silesian Conurbation; to identify host-related and environmental risk factors if the infection. Analysis of existing data will include monthly records on incidence and mortality over the period 01.01.2020-31.12.2020 and comparison of the findings with the monthly records of 2018 and 2019, for the same population. Cross-sectional epidemiological study will be located in three towne (Katowice, Sosnowiec, Gliwice). In each town a representative age-stratified sample of 2000 subjects will undergo questionnaire assessment and serological examination performed by serological test. The project corresponds with analogous population-based studies on COVID-19 in a number of countries and responds to the WHO recommendation in that field.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 6000
citizens of one of three towns (Katowice, Sosnowiec, Gliwice) with no age limits
person who is not able to contact laboratory and obtain blood sample.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Screened arm IgM and IgG antibodies assay 6000 peoples (3x2000) in all ages randomly selected from the general population of three towns (Katowice, Sosnowiec, Gliwice). From all invited is collected a venous blood samples (5ml) to assay IgM and IgG antibodies.
- Primary Outcome Measures
Name Time Method Estimation of prevalence of specific anti-SARS-CoV-2 IgM and IgG antibodies in general population. 8 months Estimation of real prevalence of elevated IgM and IgG COVID antibodies in general population will allow to estimate real number of current and past COVID infection in the population.
- Secondary Outcome Measures
Name Time Method Frequency of asymptomatic course of COVID in individuals with anti-SARS-CoV2 antibodies 8 months Prevalence of asymptomatic cases into seropositive population
Trial Locations
- Locations (1)
Diagnostyka sp zoo
🇵🇱Katowice, Poland