(In)Voluntary Assessed Quadriceps Muscle Endurance in Patients With Chronic Obstructive Pulmonary Disease: a Cross-sectional Observation Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Voluntary isokinetic work fatigue index.
研究概览
简要总结
The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD. We hypothesized a good correlation (>0.8) between the measurements.
详细描述
Rationale: Quadriceps muscle endurance is reduced in patients with COPD. However, no consensus has been reached yet on the best method to evaluate quadriceps muscle endurance. One important aspect is the large variety in protocols and devices used around the world. Commonly used and reliable measures are voluntary protocols performed on a computerized dynamometer. However, these voluntary measurements might also be influenced by external factors as patients effort or motivation. Therefore, it is important to evaluate the relation between voluntary and involuntary (i.e. electrical stimulated) assessed quadriceps muscle endurance.
Objective(s): The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD.
Study design: Cross-sectional observation study.
Study population: 20 COPD patients who perform baseline assessment at the pulmonary rehabilitation centre at Radboudumc (Nijmegen, the Netherlands).
Intervention: not applicable
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD, based on GOLD classification
- •Clinically stable according to the pulmonary physician, i.e. no exacerbation and/or hospitalization within the previous 4 weeks
- •Age between 40-80 years
- •Take part in the pulmonary rehabilitation program at Radboudumc (Nijmegen)
排除标准
- •Inability to understand the Dutch language
- •Musculoskeletal and neurological problems influencing quadriceps muscle function testing
结局指标
主要结局
Voluntary isokinetic work fatigue index.
时间窗: Performed in first week of pulmonary rehabilitation program
Voluntary isokinetic work fatigue (%) is the decline in work over 30 repetitions determined on the computerized dynamometer. The isokinetic protocol consists of 30 contractions at an angular velocity of 90°/s with maximal effort during extension and passive (submaximal) flexion. Work fatigue index = \*work first 5 repetitions - work last 5 repetitions) / work first 5 repetitions \* 100%
Voluntary isometric quadriceps endurance (time to fatigue).
时间窗: Performed in first week of pulmonary rehabilitation program
Voluntary isometric quadriceps endurance (time to fatigue in seconds) is determined on the computerized dynamometer. The isometric endurance test protocol is performed by asking participants to maintain, for as long as possible, an isometric quadriceps contraction representing 60% of the individual isometric maximal voluntary contraction (MVC) force. The test will be ended if the force of the contraction was less than 50% of the MVC for three consecutive seconds.
Electrically evoked fatigue resistance (%)
时间窗: Performed in first week of pulmonary rehabilitation program
Fatigue resistance (%) is the decline in muscle force generated using electrical stimulation.
次要结局
未报告次要终点