Measuring Voluntary Activation of the Quadriceps Femoris During Isokinetic Concentric Contractions with the Interpolated Twitch Technique (ITT) in Subjects with Neuromotor Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Voluntary Activation
研究概览
简要总结
Activation is the amount of voluntary recruitment of a muscle during voluntary contraction. Full activation implies the recruitment of all muscle fibres at their tetanic frequency. In healthy subjects, and even in sports performances, full activation may be rarely achieved despite a subjectively maximal effort.
Highly decreased activation has been observed in patients affected by various orthopaedic and neurological disorders. In these subjects, paresis may be caused or aggravated by primitive impairments of the central nervous system and/or, by stimuli arising from peripheral damaged tissues that inhibit the corticospinal or the intraspinal recruitment of motoneurones ("arthrogenous muscle weakness"). There are numerous investigations in the literature on activation measured during isometric contractions, while they are substantially missing as far as isokinetic concentric contractions are concerned. There are reasons to suppose that, contrary to what has been demonstrated for healthy subjects, in patients with various motor impairments the activation is diminished the more, the higher is the joint rotation speed.
The present study aims to investigate the amount of activation of the quadriceps femoris during subjectively maximal isometric contractions at 40° knee flexion (0°=complete extension) and isokinetic concentric contractions at an angular velocity of 100°/s in patients with various orthopaedic and neurologic conditions.
Activation will be measured on an isokinetic dynamometer, through the "interpolated twitch technique". This consists of stimulating a representative sample of the muscle belly through an electric shock. If the shock does not generate an extra force during contraction, all muscle fibres belonging to the sample reached by the electric shock can be claimed to be recruited at their tetanic frequency. Otherwise, following the stimulus, a twitch can be observed revealing submaximal voluntary recruitment of the muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age between 18 and 70 years old;
- •ability to sign the informed consent form;
- •ability to understand the instructions and to complete the motor task;
- •voluntary knee flexion-extension range of at least 70°;
- •maximal extension of angle < 30° (0°=full extension, 180° sagittal tibio-femural angle).
排除标准
- •pregnancy;
- •a history of epilepsy (to avoid the risk for seizures triggered by the stimuli);
- •Mini Mental State Examination ≤27/30;
- •implanted electro-sensitive devices;
- •any orthopedic condition limiting the articular mobility or muscular strength of the lower limbs;
- •current treatment with oral anticoagulant therapy (to avoid the risk for muscle hemorrhage);
- •medium/serius osteoporosis (femoral Bone Mineral Density on the affected side, t-score < (-3.5));
- •familiarity with the testing method.
结局指标
主要结局
Voluntary Activation
时间窗: Day 1
Voluntary Activation = \[1 - (Interpolated Twitch/Resting Twitch)\]%, where Interpolated Twitch and Resting Twitch are the peak torques caused by the electric shock during the voluntary contraction and a rest, respectively
次要结局
未报告次要终点
研究者
Luigi Tesio, Prof
MD, Director of the Department of Neuromotor Rehabilitation, Ospedale San Luca, Istituto Auxologico Italiano, IRCCS; Full Professor, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
Istituto Auxologico Italiano