Clinical study of nuclear alterations in patients undergoing in-office tooth whitening
Phase 4
- Conditions
- GenotoxicitySP3.311.300.312.289.400
- Registration Number
- RBR-4ttb63q
- Lead Sponsor
- Faculdade de Odontologia - Universidade Federal do Amazonas
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Both sexes; age between 14 and 18 years old and 31 and 50 years old; no systemic diseases (metabolic, immunological and heart diseases); with oral condition free from carious lesions or periodontal diseases; central incisor or canine color A2 or darker; six upper anterior teeth free of restorations on the buccal surface; healthy enamel; dissatisfaction with the color of your teeth; no pathological changes; physiological and medicinal
Exclusion Criteria
Dentin hypersensitivity; smoker; alcoholic; pregnant or breastfeeding; orthodontic appliance; severe crowding, presence of intrinsic spots and ages between 19 and 30 years old
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the genotoxicity of tooth whitening between age groups using the micronucleus test. For the whitening procedure to be considered safe, it is expected not to find an average difference greater than 1
- Secondary Outcome Measures
Name Time Method Evaluate the difference in the frequency of micronuclei between different age groups; evaluate the frequency of other nuclear alterations (karyolysis, karyorrhex, pycnosis, condensed chromatin, binucleated cells and nuclear button) in the gingiva of young and adult patients undergoing in-office tooth whitening