Study on the intestinal microflora characteristics and TCM syndromes of patients with hepatocellular carcinoma complicated with intestinal dysfunctio
- Conditions
- Primary hepatic carcinoma
- Registration Number
- ITMCTR2200005950
- Lead Sponsor
- Changhai Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Patients with hepatocellular carcinoma complicated with intestinal dysfunction.
(2) A history of hepatitis B cirrhosis.
(3) Child-Pugh=8, ascites quantity was grade 1.
(4) Aged 18-75, male or female, out-patient or inpatient in our department.
(5) The course of disease is more than 6 months, and the patient has persistent abdominal discomfort or pain in the last 3 months, accompanied by at least 2 of the following characteristics:
1.Abnormal frequency of defecation (defecation >3 times a day or <3 times a week);
2.Abnormal fecal traits (lumpy/hard or watery stools);
3.abnormal fecal discharge process (effort, urgency, sense of exhaustion);
4.Mucinous stool;
5.Gastrointestinal flatulence or abdominal distension.
(1) The patient's Child-Pugh was C, or the BCLC stage was D.
(2) The patient had moderate or large ascites or had upper gastrointestinal bleeding.
(3) Used gastric acid inhibitors (proton pump inhibitors and H2 receptor antagonists), microbial agents, antibacterial drugs, metformin or non-absorbable disaccharides (such as lactilose) that affect intestinal flora, or targeted therapy drugs such as sorafenib, ramvaritinib and anlotinib within the last 4 weeks.
(4) Patients with rheumatic immune diseases or systemic inflammation such as bacterial infection in the last 3 months.
(5) White blood cells detected by routine stool microscopy were > 3 / high magnification field.
Study & Design
- Study Type
- Observational study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the intestinal microflora characteristics;
- Secondary Outcome Measures
Name Time Method