Correlation of Cardiac Function on Aortic Enhancement in Coronary Angiography.

Not yet recruiting

Conditions: Disorder of arteries and arterioles, unspecified,

Registration Number: CTRI/2022/09/045872

Lead Sponsor: NA

Brief Summary: - Approval will be acquired from Institutional Research Committee, MCHP & Institutional Ethics Committee, and Kasturba Hospital Manipal for conducting the research.

- CTRI registration will be done.

- Subjects who are undergoing CT coronary angiography will be selected for the study based on Inclusion and exclusion criteria.

- Informed consent will be taken from the patient

- All the scans will be performed using Standard ECG gated coronary angiography CT Protocol of the Department.

- All the ECG gated coronary angiography are done on Philips 128 slice incisive CT scanner.

- The patientâ€™s file will be used to acquire patient information such as age, gender, weight, and height.

- For the scan, the patient is positioned supine - feet first orientation and centered for Cardiac scan by placing vertical laser on the midsagittal plane and horizontal laser on mid coronal of the thorax.

- 180 anterior to posterior scanogram in craniocaudal will be obtained from the apex of the lungs to the costophernic angle.

- A plain scan will be taken in the craniocaudal direction and the technologist will examine the image for any motion artefact after which a locator will be placed on the carina.

- The locator is placed on the carina where the pulmonary trunk divides into the right and left Pulmonary artery. Bolus tracking is used with the ROI positioned at the descending aorta and the threshold will be kept at 120 HU.

- 80ml on contrast with 40ml of saline at a flow rate of 5cc/sec is injected.

- After evaluation of the image, the patient is taken off the positioning table and the cardiac phases are reconstructed with respect to R-R interval.

- The following are the cardiac-specific parameters: Heart rate, left ventricular volume, ejection fraction, cardiac output.

- These images will be collected from the ISP server (version10).

- The images are obtained from the main cardiac phase is 75% from there the cardiac phases are reconstructed from phase 10% to phase 90% with respect to the R-R interval. The reconstructed phases are uploaded to the Cardiac comp.

- The cardiac comp has a function option that will provide us with stroke volume, ejection fraction, and cardiac output values in the form of a table.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 38

Inclusion Criteria

1)Subjects undergoing CT Coronary Angiography.
2)Age range between 18 years to 80 years.
3)Both sexes.

Exclusion Criteria

Subjects who have undergone CABG, Subjects who are allergic to Contrast Media, Subjects with Aortic regurgitation, Subjects with outflow tract obstruction, Subjects having high calcification in the aortic vessel.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cardiac output: measured in L/min	From: January 2022 To: March 2023
2. Ejection Fraction: in percentage %	From: January 2022 To: March 2023
3. Stroke volume: ml	From: January 2022 To: March 2023
4. Heart rate: beats per minute	From: January 2022 To: March 2023
5. Aortic Peak enhancement: HU	From: January 2022 To: March 2023

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Kasturba Medical College
🇮🇳
Udupi, KARNATAKA, India
Kasturba Medical College
🇮🇳Udupi, KARNATAKA, India
Clireen Paes
Principal investigator
8861651928
clireen.paes@learner.manipal.edu