Comparative Effects of Recombinant Human Brain Natriuretic Peptide and Dobutamine on Acute Decompensated Heart Failure Patients With Different Blood BNP Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 104
- 主要终点
- left ventricular ejection fraction (LVEF) in the High and Extra-high BNP Groups
研究概览
简要总结
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide (rhBNP) with dobutamine on acute decompensated heart failure patients with different blood BNP levels
详细描述
Patients with acute decompensated heart failure (ADHF) whose left ventricular ejection fraction(LVEF) was <40%, were assigned to a high BNP group (BNP ≤ 3000 pg/mL) or an extra-high BNP group (BNP > 3000 pg/mL) , depending on their admission plasma BNP levels. Each group was then subdivided into rhBNP or dobutamine subgroups according to intravenous administration with either rhBNP or dobutamine for 24-72h. The effects of rhBNP and dobutamine on patients in the high and extra-high BNP groups were compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients were classified as NYHA class III-IV
- •ejection fraction <40%
排除标准
- •intravenous administration with rhBNP or dobutamine in the 2 weeks before study entry
- •acute myocardial infarction
- •significant valvular stenosis
- •serious ventricular arrhythmia (frequent ventricular premature beat of >5 bpm, nonsustained and sustained ventricular tachycardia)
- •blood pressure <95/60 mmHg or >140/90 mmHg
- •hypovolemia
- •hepatic or renal impairment
- •pregnant and lactating women.
结局指标
主要结局
left ventricular ejection fraction (LVEF) in the High and Extra-high BNP Groups
时间窗: baseline and 5 days
Left ventricle end diastolic dimension (LVEDD)in the High and Extra-high BNP Groups
时间窗: baseline and 5 days
Blood BNP in the High and Extra-high BNP Groups
时间窗: baseline and 5 days
次要结局
- Blood Pressure (mmHg)(baseline and 5 days)
- Heart Rate(baseline and 5 days)
- Changes in New York Heart Association (NYHA) Class from Baseline to Day 5 after Treatment(baseline and 5 days)
- Plasma Creatinine(baseline and 5 days)
研究者
Haiyan PAN
associate chief physician
Nantong University